AustralieFrV1, Main, Exploration, bibRecord, 001B51

Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group.

Identifieur interne : 001B51 ( Main/Exploration ); précédent : 001B50; suivant : 001B52

Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group.

Auteurs : J. Laubach [États-Unis] ; L. Garderet [France] ; A. Mahindra [États-Unis] ; G. Gahrton [Suède] ; J. Caers [Belgique] ; O. Sezer [Turquie] ; P. Voorhees [États-Unis] ; X. Leleu [France] ; H E Johnsen [Danemark] ; M. Streetly [Royaume-Uni] ; A. Jurczyszyn [Pologne] ; H. Ludwig [Autriche] ; U-H Mellqvist [Suède] ; W-J Chng [Singapour] ; L. Pilarski [Canada] ; H. Einsele [Allemagne] ; J. Hou [République populaire de Chine] ; I. Turesson [Suède] ; E. Zamagni [Italie] ; C S Chim [République populaire de Chine] ; A. Mazumder [États-Unis] ; J. Westin [Suède] ; J. Lu [République populaire de Chine] ; T. Reiman ; S. Kristinsson [Suède] ; D. Joshua [Australie] ; M. Roussel [France] ; P. O'Gorman [Irlande (pays)] ; E. Terpos [Grèce] ; P. Mccarthy [États-Unis] ; M. Dimopoulos [Grèce] ; P. Moreau [France] ; R Z Orlowski [États-Unis] ; J S Miguel [Espagne] ; K C Anderson [États-Unis] ; A. Palumbo [Italie] ; S. Kumar [États-Unis] ; V. Rajkumar [États-Unis] ; B. Durie [États-Unis] ; P G Richardson [États-Unis]

Source :

Leukemia [ 1476-5551 ] ; 2016.

RBID : pubmed:26710887

Descripteurs français

KwdFr :
- Antinéoplasiques (usage thérapeutique), Guides de bonnes pratiques cliniques comme sujet, Humains, Myélome multiple (), Myélome multiple (anatomopathologie), Myélome multiple (diagnostic), Myélome multiple (traitement médicamenteux), Prise en charge de la maladie, Récidive, Thérapie de rattrapage (), Transplantation de cellules souches hématopoïétiques ().
MESH :
- anatomopathologie : Myélome multiple.
- diagnostic : Myélome multiple.
- traitement médicamenteux : Myélome multiple.
- usage thérapeutique : Antinéoplasiques.
- Guides de bonnes pratiques cliniques comme sujet, Humains, Myélome multiple, Prise en charge de la maladie, Récidive, Thérapie de rattrapage, Transplantation de cellules souches hématopoïétiques.

English descriptors

KwdEn :
- Antineoplastic Agents (therapeutic use), Disease Management, Hematopoietic Stem Cell Transplantation (methods), Humans, Multiple Myeloma (diagnosis), Multiple Myeloma (drug therapy), Multiple Myeloma (pathology), Multiple Myeloma (therapy), Practice Guidelines as Topic, Recurrence, Salvage Therapy (methods).
MESH :
- chemical , therapeutic use : Antineoplastic Agents.
- diagnosis : Multiple Myeloma.
- drug therapy : Multiple Myeloma.
- methods : Hematopoietic Stem Cell Transplantation, Salvage Therapy.
- pathology : Multiple Myeloma.
- therapy : Multiple Myeloma.
- Disease Management, Humans, Practice Guidelines as Topic, Recurrence.

Abstract

The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM.

DOI: 10.1038/leu.2015.356
PubMed: 26710887

Affiliations:

Le document en format XML

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<author><name sortKey="Joshua, D" sort="Joshua, D" uniqKey="Joshua D" first="D" last="Joshua">D. Joshua</name>
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<author><name sortKey="Terpos, E" sort="Terpos, E" uniqKey="Terpos E" first="E" last="Terpos">E. Terpos</name>
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<country xml:lang="fr">Grèce</country>
<wicri:regionArea>National and Kapodistrian University of Athens, School of Medicine, Athens</wicri:regionArea>
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<author><name sortKey="Mccarthy, P" sort="Mccarthy, P" uniqKey="Mccarthy P" first="P" last="Mccarthy">P. Mccarthy</name>
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<author><name sortKey="Dimopoulos, M" sort="Dimopoulos, M" uniqKey="Dimopoulos M" first="M" last="Dimopoulos">M. Dimopoulos</name>
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<author><name sortKey="Moreau, P" sort="Moreau, P" uniqKey="Moreau P" first="P" last="Moreau">P. Moreau</name>
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<author><name sortKey="Orlowski, R Z" sort="Orlowski, R Z" uniqKey="Orlowski R" first="R Z" last="Orlowski">R Z Orlowski</name>
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<author><name sortKey="Miguel, J S" sort="Miguel, J S" uniqKey="Miguel J" first="J S" last="Miguel">J S Miguel</name>
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<author><name sortKey="Anderson, K C" sort="Anderson, K C" uniqKey="Anderson K" first="K C" last="Anderson">K C Anderson</name>
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<author><name sortKey="Palumbo, A" sort="Palumbo, A" uniqKey="Palumbo A" first="A" last="Palumbo">A. Palumbo</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino, Italy.</nlm:affiliation>
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<wicri:regionArea>Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino</wicri:regionArea>
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<author><name sortKey="Kumar, S" sort="Kumar, S" uniqKey="Kumar S" first="S" last="Kumar">S. Kumar</name>
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<author><name sortKey="Rajkumar, V" sort="Rajkumar, V" uniqKey="Rajkumar V" first="V" last="Rajkumar">V. Rajkumar</name>
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<wicri:regionArea>Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
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<author><name sortKey="Durie, B" sort="Durie, B" uniqKey="Durie B" first="B" last="Durie">B. Durie</name>
<affiliation wicri:level="2"><nlm:affiliation>Cedars-Sinai Outpatient Cancer Center, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cedars-Sinai Outpatient Cancer Center, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
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<author><name sortKey="Mccarthy, P" sort="Mccarthy, P" uniqKey="Mccarthy P" first="P" last="Mccarthy">P. Mccarthy</name>
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<author><name sortKey="Dimopoulos, M" sort="Dimopoulos, M" uniqKey="Dimopoulos M" first="M" last="Dimopoulos">M. Dimopoulos</name>
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<author><name sortKey="Miguel, J S" sort="Miguel, J S" uniqKey="Miguel J" first="J S" last="Miguel">J S Miguel</name>
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<author><name sortKey="Anderson, K C" sort="Anderson, K C" uniqKey="Anderson K" first="K C" last="Anderson">K C Anderson</name>
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<author><name sortKey="Palumbo, A" sort="Palumbo, A" uniqKey="Palumbo A" first="A" last="Palumbo">A. Palumbo</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Rajkumar, V" sort="Rajkumar, V" uniqKey="Rajkumar V" first="V" last="Rajkumar">V. Rajkumar</name>
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<author><name sortKey="Richardson, P G" sort="Richardson, P G" uniqKey="Richardson P" first="P G" last="Richardson">P G Richardson</name>
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<country xml:lang="fr">États-Unis</country>
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<series><title level="j">Leukemia</title>
<idno type="eISSN">1476-5551</idno>
<imprint><date when="2016" type="published">2016</date>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hematopoietic Stem Cell Transplantation</term>
<term>Salvage Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Disease Management</term>
<term>Humans</term>
<term>Practice Guidelines as Topic</term>
<term>Recurrence</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Guides de bonnes pratiques cliniques comme sujet</term>
<term>Humains</term>
<term>Myélome multiple</term>
<term>Prise en charge de la maladie</term>
<term>Récidive</term>
<term>Thérapie de rattrapage</term>
<term>Transplantation de cellules souches hématopoïétiques</term>
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<front><div type="abstract" xml:lang="en">The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM.</div>
</front>
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Serveur d'exploration sur les relations entre la France et l'Australie

Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group.

Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group.

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